High resolution CT with dynamic scanning, demonstrating the pituitary tuft, the pituitary enhancement and the related vascular structures, is of major benefit for the diagnosis of pituitary lesions. Perfection of examination techniques is essential for accurate application of the modality to detect subtle diagnostic signs. A good knowledge of normal anatomy and variants of the sella turcica and pituitary gland permits one to avoid most of the misdiagnoses. Since the CT findings are often non-specific to tissues, clinical endocrinological correlation is essential. The technique also allows consistent assessment of the extent of the disease to permit better treatment planning and effective follow-up of patients after therapy.