Pancreatic cancer: Current research and future directions

Marco Falasca; Minkyoung Kim; Ilaria Casari

doi:10.1016/j.bbcan.2016.01.001

Pancreatic cancer: Current research and future directions

Biochim Biophys Acta. 2016 Apr;1865(2):123-32. doi: 10.1016/j.bbcan.2016.01.001. Epub 2016 Jan 12.

Authors

Marco Falasca¹, Minkyoung Kim², Ilaria Casari²

Affiliations

¹ Metabolic Signalling Group, School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth, Western Australia, Australia. Electronic address: marco.falasca@curtin.edu.au.
² Metabolic Signalling Group, School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth, Western Australia, Australia.

PMID: 26794394
DOI: 10.1016/j.bbcan.2016.01.001

Abstract

Despite the survival rate advancements in different types of cancer in the last 40 years, the perspective for pancreatic cancer patients has seen no substantial changes. Indeed, the five year survival rate remains around 5%. Nevertheless, in the last decade we have witnessed an increased interest in pancreatic cancer biology and this has produced a substantial increment in our knowledge on pancreatic cancer progression. The big challenge is now to translate this knowledge in better outcomes for patients. The aim of this review is to describe the latest discoveries and advancements in pancreatic cancer research and to discuss future directions.

Keywords: Cancer metabolism; Exosomes; MicroRNA; Pancreatic cancer; Tumour stroma.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Carcinoma, Pancreatic Ductal / pathology
Exosomes
Humans
MicroRNAs / physiology
Pancreatic Neoplasms / genetics
Pancreatic Neoplasms / pathology*
Stromal Cells / physiology
Tumor Microenvironment

Substances

MicroRNAs