Toxocara canis: Larvicidal activity of fatty acid amides

Bioorg Med Chem Lett. 2016 Feb 1;26(3):739-741. doi: 10.1016/j.bmcl.2016.01.002. Epub 2016 Jan 5.

Abstract

Considering the therapeutic potential of fatty acid amides, the present study aimed to evaluate their in vitro activity against Toxocara canis larvae and their cytotoxicity for the first time. Linoleylpyrrolidilamide was the most potent, with a minimal larvicidal concentration (MLC) of 0.05 mg/mL and 27% cytotoxicity against murine peritoneal macrophages C57BL/6 mice, as assessed by the MTT assay.

Keywords: Chemical compounds; Chemotherapy; Cytotoxicity; Toxocarosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Amides / pharmacology*
  • Animals
  • Antiprotozoal Agents / chemistry*
  • Antiprotozoal Agents / pharmacology*
  • Fatty Acids / chemistry*
  • Larva / drug effects
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Macrophages / parasitology
  • Mice
  • Mice, Inbred C57BL
  • Toxocara canis / drug effects*
  • Toxocara canis / growth & development

Substances

  • Amides
  • Antiprotozoal Agents
  • Fatty Acids