Abstract
The influence of the chirality of semiconductor nanocrystals, CdSe/ZnS quantum dots (QDs) capped with L- and D-cysteine, on the efficiency of their uptake by living Ehrlich Ascite carcinoma cells is studied by spectral- and time-resolved fluorescence microspectroscopy. We report an evident enantioselective process where cellular uptake of the L-Cys QDs is almost twice as effective as that of the D-Cys QDs. This finding paves the way for the creation of novel approaches to control the biological properties and behavior of nanomaterials in living cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Transport
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Cadmium Compounds / analysis
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Cadmium Compounds / metabolism*
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Cell Line
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Cysteine / chemistry
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Cysteine / metabolism*
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Fluorescence
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Mice
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Optical Imaging
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Quantum Dots / analysis
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Quantum Dots / metabolism*
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Selenium Compounds / analysis
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Selenium Compounds / metabolism*
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Stereoisomerism
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Sulfides / analysis
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Sulfides / metabolism*
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Zinc Compounds / analysis
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Zinc Compounds / metabolism*
Substances
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Cadmium Compounds
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Selenium Compounds
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Sulfides
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Zinc Compounds
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cadmium selenide
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Cysteine
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zinc sulfide