Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

Chiara Leoni; Roberta Onesimo; Valentina Giorgio; Antonella Diamanti; Daniela Giorgio; Lucilla Martini; Aurora Rossodivita; Marco Tartaglia; Giuseppe Zampino

doi:10.1016/j.jpeds.2015.11.076

Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

J Pediatr. 2016 Mar:170:322-4. doi: 10.1016/j.jpeds.2015.11.076. Epub 2016 Jan 9.

Authors

Chiara Leoni¹, Roberta Onesimo¹, Valentina Giorgio², Antonella Diamanti³, Daniela Giorgio¹, Lucilla Martini¹, Aurora Rossodivita¹, Marco Tartaglia⁴, Giuseppe Zampino⁵

Affiliations

¹ Center for Rare Diseases, Department of Pediatrics, Catholic University, Rome, Italy.
² Department of Pediatrics, Catholic University, Rome, Italy.
³ Artificial Nutrition Unit, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
⁴ Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
⁵ Center for Rare Diseases, Department of Pediatrics, Catholic University, Rome, Italy. Electronic address: alipino@alice.it.

PMID: 26778095
DOI: 10.1016/j.jpeds.2015.11.076

Abstract

Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Case-Control Studies
Child
Child, Preschool
Costello Syndrome / complications*
Costello Syndrome / metabolism
Energy Metabolism*
Failure to Thrive / etiology*
Failure to Thrive / metabolism
Female
Humans
Male
Proto-Oncogene Mas
Rest / physiology*
Young Adult