The Structure-Activity Relationship of the Antioxidant Peptides from Natural Proteins

Molecules. 2016 Jan 12;21(1):72. doi: 10.3390/molecules21010072.

Abstract

Peptides derived from dietary proteins, have been reported to display significant antioxidant activity, which may exert notably beneficial effects in promoting human health and in food processing. Recently, much research has focused on the generation, separation, purification and identification of novel peptides from various protein sources. Some researchers have tried to discover the structural characteristics of antioxidant peptides in order to lessen or avoid the tedious and aimless work involving the ongoing generated peptide preparation schemes. This review aims to summarize the current knowledge on the relationship between the structural features of peptides and their antioxidant activities. The relationship between the structure of the precursor proteins and their abilities to release antioxidant fragments will also be summarized and inferred. The preparation methods and antioxidant capacity evaluation assays of peptides and a prediction scheme of quantitative structure-activity relationship (QSAR) will also be pointed out and discussed.

Keywords: antioxidant peptides; proteins; structure-activity relationship.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / chemistry*
  • Amino Acids / metabolism
  • Amino Acids / pharmacology
  • Antioxidants / chemistry*
  • Antioxidants / metabolism
  • Antioxidants / pharmacology
  • Biological Products / administration & dosage
  • Dietary Proteins / administration & dosage
  • Dietary Proteins / metabolism*
  • Dietary Proteins / pharmacology
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Molecular Sequence Data
  • Peptide Fragments / chemistry*
  • Peptide Fragments / metabolism
  • Peptide Fragments / pharmacology
  • Proteolysis
  • Quantitative Structure-Activity Relationship
  • Reactive Oxygen Species / antagonists & inhibitors
  • Reactive Oxygen Species / metabolism
  • Static Electricity

Substances

  • Amino Acids
  • Antioxidants
  • Biological Products
  • Dietary Proteins
  • Peptide Fragments
  • Reactive Oxygen Species