The TNF-α-308G/A Polymorphism is Not Associated with Ocular Chlamydia trachomatis Infection in Han Chinese Children

Ophthalmic Genet. 2016 Jun;37(2):245-7. doi: 10.3109/13816810.2015.1028650. Epub 2016 Jan 15.

Abstract

Objective: To investigate the association between the TNF-α-308G/A polymorphism and ocular chlamydia trachomatis (C. Trachomatis) infection among Han Chinese children.

Methods: 248 patients and 162 matched healthy controls were recruited. The diagnosis of ocular C. Trachomatis infection was given after clinical observation and latex immunochromatography tests. The TNF-α-308G/A polymorphism was genotyped by sequencing.

Results: No association was found between the TNF-α-308G/A polymorphism and ocular C. Trachomatis infection.

Conclusions: The TNF-α-308A polymorphism is unlikely to play a major role in the risk for ocular C. Trachomatis in the Chinese population.

Keywords: Association; TNF-α-308G/A; chinese population; trachoma.

MeSH terms

  • Asian People / genetics*
  • Child
  • China / epidemiology
  • Chlamydia trachomatis / isolation & purification*
  • Eye Infections, Bacterial / genetics*
  • Eye Infections, Bacterial / microbiology
  • Female
  • Gene Frequency
  • Genotyping Techniques
  • Humans
  • Male
  • Polymorphism, Single Nucleotide*
  • Trachoma / genetics*
  • Trachoma / microbiology
  • Tumor Necrosis Factor-alpha / genetics*

Substances

  • Tumor Necrosis Factor-alpha