Objective: To investigate the association between the TNF-α-308G/A polymorphism and ocular chlamydia trachomatis (C. Trachomatis) infection among Han Chinese children.
Methods: 248 patients and 162 matched healthy controls were recruited. The diagnosis of ocular C. Trachomatis infection was given after clinical observation and latex immunochromatography tests. The TNF-α-308G/A polymorphism was genotyped by sequencing.
Results: No association was found between the TNF-α-308G/A polymorphism and ocular C. Trachomatis infection.
Conclusions: The TNF-α-308A polymorphism is unlikely to play a major role in the risk for ocular C. Trachomatis in the Chinese population.
Keywords: Association; TNF-α-308G/A; chinese population; trachoma.