Can Insulin Production Suppress β Cell Growth?

Cell Metab. 2016 Jan 12;23(1):4-5. doi: 10.1016/j.cmet.2015.12.016.

Abstract

While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation.

Publication types

  • Comment

MeSH terms

  • Cell Cycle
  • Cell Proliferation / drug effects
  • Insulin / pharmacology*
  • Insulin-Like Growth Factor I / metabolism
  • Insulin-Secreting Cells / metabolism*

Substances

  • Insulin
  • Insulin-Like Growth Factor I