Genetic polymorphisms associated with heart failure: A literature review

Mengqi Guo; Guanlun Guo; Xiaoping Ji

doi:10.1177/0300060515604755

Genetic polymorphisms associated with heart failure: A literature review

J Int Med Res. 2016 Feb;44(1):15-29. doi: 10.1177/0300060515604755. Epub 2016 Jan 14.

Authors

Mengqi Guo¹, Guanlun Guo², Xiaoping Ji³

Affiliations

¹ Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, China.
² Hubei Key Laboratory of Advanced Technology of Automotive Components, School of Automotive Engineering, Wuhan University of Technology, Wuhan, China.
³ Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, China jxp1964@hotmail.com.

Abstract

Objective: To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure.

Methods: Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and February 2015.

Results: Eighty-two articles covering 29 genes and 39 polymorphisms were identified.

Conclusion: Genetic association studies of heart failure have been highly controversial. There may be interaction or synergism of several genetic variants that together result in the ultimate pathological phenotype for heart failure.

Keywords: Heart failure; genetic polymorphism; prognosis; susceptibility; therapy.

Publication types

Review

MeSH terms

Epistasis, Genetic
Genetic Association Studies*
Genetic Predisposition to Disease*
Heart Failure / genetics*
Humans
Polymorphism, Single Nucleotide / genetics*
Prognosis