Cassane diterpenes from the seed kernels of Caesalpinia sappan

Hai Xuan Nguyen; Nhan Trung Nguyen; Phu Hoang Dang; Phuoc Thi Ho; Mai Thanh Thi Nguyen; Mao Van Can; Dya Fita Dibwe; Jun-Ya Ueda; Suresh Awale

doi:10.1016/j.phytochem.2015.12.018

Cassane diterpenes from the seed kernels of Caesalpinia sappan

Phytochemistry. 2016 Feb:122:286-293. doi: 10.1016/j.phytochem.2015.12.018. Epub 2016 Jan 5.

Authors

Hai Xuan Nguyen¹, Nhan Trung Nguyen¹, Phu Hoang Dang¹, Phuoc Thi Ho¹, Mai Thanh Thi Nguyen², Mao Van Can³, Dya Fita Dibwe⁴, Jun-Ya Ueda⁴, Suresh Awale⁵

Affiliations

¹ Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
² Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam. Electronic address: nttmai@hcmus.edu.vn.
³ Vietnam Military Medical University, Ha Noi, Viet Nam.
⁴ Division of Natural Drug Discovery, Department of Translational Research, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
⁵ Division of Natural Drug Discovery, Department of Translational Research, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: suresh@inm.u-toyama.ac.jp.

PMID: 26769396
DOI: 10.1016/j.phytochem.2015.12.018

Abstract

Eight structurally diverse cassane diterpenes named tomocins A-H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were determined by extensive NMR and CD spectroscopic analysis. Among the isolated compounds, tomocin A, phanginin A, F, and H exhibited mild preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived condition without causing toxicity in normal nutrient-rich conditions.

Keywords: Antiausterity agent; Caesalpinia sappan; Caesalpiniaceae; Cassane diterpene; PANC-1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Caesalpinia / chemistry*
Cell Line, Tumor
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pancreatic Neoplasms / drug therapy
Seeds / chemistry

Substances

Diterpenes