The role of HIF in immunity and inflammation

Mol Aspects Med. 2016 Feb-Mar:47-48:24-34. doi: 10.1016/j.mam.2015.12.004. Epub 2016 Jan 6.

Abstract

Uncontrolled or non-resolving inflammation underpins a range of disease states including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Hypoxia is a prominent feature of chronically inflamed tissues. This is due to elevated oxygen consumption by highly metabolically active inflamed resident cells and activated infiltrating immunocytes, as well as diminished oxygen supply due to vascular dysfunction. Tissue hypoxia can have a significant impact upon inflammatory signaling pathways in immune and non-immune cells and this can impact upon disease progression. In this review, we will discuss the relationship between tissue hypoxia and inflammation and identify how hypoxia-sensitive signaling pathways are potential therapeutic targets in chronic inflammatory disease.

Keywords: Hypoxia; hypoxia inducible factor; inflammation; leukocyte.

Publication types

  • Review

MeSH terms

  • Adaptive Immunity*
  • Animals
  • Chronic Disease
  • Disease Models, Animal
  • Humans
  • Hypoxia / immunology
  • Hypoxia-Inducible Factor 1 / genetics
  • Hypoxia-Inducible Factor 1 / metabolism*
  • Immunity, Innate*
  • Inflammation / immunology*
  • Inflammation / therapy
  • NF-kappa B / genetics
  • NF-kappa B / metabolism*
  • Signal Transduction

Substances

  • Hypoxia-Inducible Factor 1
  • NF-kappa B