When Less Is Better: ER Stress and Beta Cell Proliferation

Jing Yong; Pamela Itkin-Ansari; Randal J Kaufman

doi:10.1016/j.devcel.2015.12.030

When Less Is Better: ER Stress and Beta Cell Proliferation

Dev Cell. 2016 Jan 11;36(1):4-6. doi: 10.1016/j.devcel.2015.12.030.

Authors

Jing Yong¹, Pamela Itkin-Ansari², Randal J Kaufman³

Affiliations

¹ Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
² Development and Aging Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
³ Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: rkaufman@sbpdiscovery.org.

PMID: 26766438
DOI: 10.1016/j.devcel.2015.12.030

Abstract

Pancreatic β cells synthesize and secrete insulin to increase anabolic metabolism in an organism, and insulin synthesis has long been suspected to inhibit β cell replication. Recently in Cell Metabolism, Szabat et al. (2015) present evidence that deletion of Insulin genes alleviates ER stress and promotes mature β cell replication.

Publication types

Comment

MeSH terms

Apoptosis / genetics
Cell Differentiation
Cell Proliferation
Endoplasmic Reticulum / metabolism*
Endoplasmic Reticulum Stress
Insulin / metabolism
Insulin-Secreting Cells / metabolism*

Substances

Insulin