Age, weight and decompression sickness in rats

Arch Physiol Biochem. 2016;122(2):67-9. doi: 10.3109/13813455.2016.1140787. Epub 2016 Mar 12.

Abstract

Objective: The aim of this study was to determine if, after controlling for weight, age is associated with decompression sickness (DCS) in rats.

Methods: Following compression-decompression, male rats aged 11 weeks were observed for DCS. After two weeks recovery, surviving rats were re-dived using the same compression-decompression profile.

Results: In this experiment, there was a clear difference between DCS outcome at ages 11 or 13 weeks in matched rats (p = 0.002).

Discussion: Even with weight included in the model, age was significantly associated with DCS (p = 0.01), yet after removal of weight the association was much stronger (p = 0.002).

Conclusion: We believe that age is likely to be found associated with the probability of DCS in a larger dataset with a wider range of parameters, after accounting for the effect of weight.

Keywords: Decompression illness; Long-Evans; diving; regression modeling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging*
  • Animals
  • Body Weight*
  • Decompression Sickness / physiopathology*
  • Male
  • Rats
  • Survival Analysis