1 Nuffield Department of Clinical Neurosciences and Oxford Medical School, University of Oxford, Oxford OX3 9DU, UK.
2 Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
3 Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK. Medical Sciences Division, University of Oxford, Oxford OX3 9DU, UK. alastair.buchan@medsci.ox.ac.uk.