Autoimmune uveitis: study of treatment therapies
Einstein (Sao Paulo). 2010 Mar;8(1):117-21.
doi: 10.1590/S1679-45082010RB1416.
[Article in
English,
Portuguese]
Affiliations
- 1 Vision Institute, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP, Brazil.
- 2 Department of Immunology, Instituto de Ciências Biomédicas, Universidade de São Paulo - USP, São Paulo, SP, Brazil.
- 3 Laboratory of Immunochemistry of Instituto Butantan, São Paulo, SP, Brazil.
- 4 Instituto da Visão, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP, Brazil.
- 5 Instituto Israelita de Ensino e Pesquisa Albert Einstein - IIEPAE, São Paulo, SP, Brazil.
Abstract
Experimental autoimmune uveitis is an organ-specific T-cell mediated autoimmune disease characterized by inflammation and consequent destruction of the neural retina and adjacent tissues. Inflammation in experimental autoimmune uveitis may be induced in rodents by immunization with retinal antigens, such as interphotoreceptor retinoid-binding protein. We present a review of experimental studies that correlate primary immunobiological functions with this chronic disease and the possible use of molecules for the treatment of autoimmune uveitis.