A New Fluorescent Sensor Based on Bisindolizine Derivative

J Fluoresc. 2016 Mar;26(2):725-9. doi: 10.1007/s10895-015-1760-5. Epub 2016 Jan 13.

Abstract

A fluorescent sensor based on 1,2,1',2'- Tetra(methoxycarbonyl)- 3,3'- bis(p-methylbenzoyl)- 7,7'-bisindolizine (MBI) showing excellent selectivity towards Fe(3+) ions was developed. Under optimized experimental conditions, the fluorescence intensity of 1,2,1',2'- Tetramethoxycarbonyl- 3,3'- bis(p-methylbenzoyl)- 7,7'-bisindolizine was quenched linearly by Fe(3+) ions in the range of 2.00 × 10(-2) to 4.76 × 10(-3) M. The limit of detection was found to be 3.17 × 10(-3) M. The mechanism for quenching was investigated. The developed sensor was applied for the determination of Fe(3+) in pharmaceutical samples.

Keywords: Bisindolizine; Fe3+; Fluorescence quenching; Fluorescent sensor; Microwave synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / methods*
  • Capsules / analysis*
  • Fluorescence
  • Fluorescent Dyes / chemistry*
  • Hydrogen-Ion Concentration
  • Indolizines / chemistry*
  • Iron / analysis*
  • Pharmaceutical Preparations / analysis*
  • Pharmaceutical Preparations / chemistry
  • Spectrometry, Fluorescence

Substances

  • Capsules
  • Fluorescent Dyes
  • Indolizines
  • Pharmaceutical Preparations
  • Iron