Microbial production of poly(lactate-co-3-hydroxybutyrate) from hybrid Miscanthus-derived sugars

Biosci Biotechnol Biochem. 2016;80(4):818-20. doi: 10.1080/09168451.2015.1116933. Epub 2016 Jan 13.

Abstract

P[(R)-lactate-co-(R)-3-hydroxybutyrate] [P(LA-co-3HB)] was produced in engineered Escherichia coli using lignocellulose-derived hydrolysates from Miscanthus × giganteus (hybrid Miscanthus) and rice straw. Hybrid Miscanthus-derived hydrolysate exhibited no negative effect on polymer production, LA fraction, and molecular weight of the polymer, whereas rice straw-derived hydrolysate reduced LA fraction. These results revealed that P(LA-co-3HB) was successfully produced from hybrid Miscanthus-derived sugars.

Keywords: bio-based polyester; biorefinery; biosynthesis; lignocellulosic biomass.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomass
  • Carbohydrate Metabolism*
  • Hydroxybutyrates / metabolism*
  • Lactic Acid / metabolism*
  • Poaceae / metabolism*
  • Polyesters / metabolism*

Substances

  • Hydroxybutyrates
  • Polyesters
  • poly-beta-hydroxybutyrate
  • Lactic Acid