Drug-Related Eyelid Nystagmus: Two Cases of a Rare Clinical Phenomenon Related to Carbamazepine and Derivatives

Clin Neuropharmacol. 2016 Jan-Feb;39(1):49-50. doi: 10.1097/WNF.0000000000000125.

Abstract

Background: Eyelid nystagmus is a rare clinical phenomenon described mostly related to brainstem or cerebellum lesions. The mechanism of this phenomenon is incompletely understood.

Patients and methods: We report 2 cases of eyelid nystagmus induced by carbamazepine and oxcarbazepine intoxication.

Conclusions: Carbamazepine and derivatives may induce eyelid nystagmus in the setting of acute intoxication. To the best of our knowledge, these are the first cases of drug-related eyelid nystagmus.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anticonvulsants / adverse effects*
  • Carbamazepine / adverse effects*
  • Epilepsy / drug therapy
  • Female
  • Humans
  • Middle Aged
  • Nystagmus, Pathologic / chemically induced*

Substances

  • Anticonvulsants
  • Carbamazepine