Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity

Chia-I Yen; Szu-Mam Liu; Wei-Shang Lo; Jhe-Wei Wu; Yi-Hsin Liu; Rong-Jie Chein; Renqiang Yang; Kevin C-W Wu; Jih Ru Hwu; Nianhan Ma; Fa-Kuen Shieh

doi:10.1002/chem.201505005

Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity

Chemistry. 2016 Feb 24;22(9):2925-9. doi: 10.1002/chem.201505005. Epub 2016 Jan 28.

Authors

Chia-I Yen¹, Szu-Mam Liu², Wei-Shang Lo¹, Jhe-Wei Wu¹, Yi-Hsin Liu¹, Rong-Jie Chein³, Renqiang Yang⁴, Kevin C-W Wu⁵, Jih Ru Hwu⁶, Nianhan Ma⁷, Fa-Kuen Shieh⁸

Affiliations

¹ Department of Chemistry, National Central University, Taoyuan, 32001, Taiwan.
² Department of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, 32001, Taiwan.
³ Institute of Chemistry, Academia Sinica, Nankang, Taipei, 11529, Taiwan.
⁴ CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, P. R. China.
⁵ Department of Chemical Engineering, National Taiwan University, Taipei, 10617, Taiwan.
⁶ Department of Chemistry & Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, 30013, Taiwan.
⁷ Department of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, 32001, Taiwan. nianhan.ma@gmail.com.
⁸ Department of Chemistry, National Central University, Taoyuan, 32001, Taiwan. fshieh@ncu.edu.tw.

PMID: 26756283
DOI: 10.1002/chem.201505005

Abstract

Using a simple method, the aldehyde groups of zeolitic imidazolate framework-90 (ZIF-90) nanocrystals were converted into carboxyl, amino, and thiol groups, without affecting the integrity of the framework. Notably, for the first time, correlations between functionality and cytotoxicity are also demonstrated via in vitro cytotoxicity assays. The positive charged aminated-ZIF-90 presumably results in either perturbation of cell membrane, more efficient cell uptake, or both. Therefore, the half-maximal effective (EC50 ) concentration of aminated-ZIF-90 has a higher cytotoxicity of about 30 μg mL(-1) .

Keywords: ZIF-90; cytotoxicity; drug carriers; metal-organic frameworks; post-modification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry
Amination
Imidazoles / chemistry*
Imidazoles / toxicity
Models, Molecular
Nanoparticles / chemistry*
Sulfhydryl Compounds / chemistry
Zeolites / chemistry*
Zeolites / toxicity*

Substances

Aldehydes
Imidazoles
Sulfhydryl Compounds
Zeolites