The role of ANGPTL3 in controlling lipoprotein metabolism

Endocrine. 2016 May;52(2):187-93. doi: 10.1007/s12020-015-0838-9. Epub 2016 Jan 11.

Abstract

Angiopoietin-like protein 3 (ANGPTL3) is a secretory protein regulating plasma lipid levels via affecting lipoprotein lipase- and endothelial lipase-mediated hydrolysis of triglycerides and phospholipids. ANGPTL3-deficiency due to loss-of-function mutations in the ANGPTL3 gene causes familial combined hypobetalipoproteinemia (FHBL2, OMIM # 605019), a phenotype characterized by low concentration of all major lipoprotein classes in circulation. ANGPTL3 is therefore a potential therapeutic target to treat combined hyperlipidemia, a major risk factor for atherosclerotic coronary heart disease. This review focuses on the mechanisms behind ANGPTL3-deficiency induced FHBL2.

Keywords: ANGPTL3; FHBL2; LPL; Lipoprotein metabolism; Triglycerides.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Angiopoietin-Like Protein 3
  • Angiopoietin-like Proteins
  • Angiopoietins / physiology*
  • Female
  • Humans
  • Hypobetalipoproteinemias / genetics*
  • Hypobetalipoproteinemias / metabolism
  • Lipid Metabolism / genetics*
  • Lipoproteins / metabolism*
  • Male
  • Middle Aged

Substances

  • ANGPTL3 protein, human
  • Angiopoietin-Like Protein 3
  • Angiopoietin-like Proteins
  • Angiopoietins
  • Lipoproteins