Analysis of Antiviral Properties of Hexoral In Vitro against Some Viruses that Cause Acute Respiratory Infections and Herpes

P G Deryabin; G A Galegov; V A Andronova; A G Botikov

doi:10.1007/s10517-016-3169-9

Analysis of Antiviral Properties of Hexoral In Vitro against Some Viruses that Cause Acute Respiratory Infections and Herpes

Bull Exp Biol Med. 2016 Jan;160(3):353-6. doi: 10.1007/s10517-016-3169-9. Epub 2016 Jan 11.

Authors

P G Deryabin¹, G A Galegov², V A Andronova², A G Botikov²

Affiliations

¹ D. I. Ivanovsky Research Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia. pg_deryabin@mail.ru.
² D. I. Ivanovsky Research Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.

PMID: 26750930
DOI: 10.1007/s10517-016-3169-9

Abstract

Antiviral properties of Hexoral (0.1% solution and 0.2% aerosol for local application) and its constituent hexetidine against viruses causing human respiratory tract infections and herpes virus were studied in vitro. It was found that non-cytotoxic concentrations of hexetidine (alone and as a component of Hexoral) attenuated infectious properties of highly virulent influenza virus A/H5N1, pandemic influenza virus A/H1N1pdm, respiratory syncytial virus, and herpes simplex virus type 1 after a short-term exposure (30 sec) by 100 or more times. It was found that hexidine mostly contributes to the virucidal effect of Hexoral.

Keywords: Hexoral; antiviral properties; cell cultures; influenza virus.

MeSH terms

Animals
Antiviral Agents / pharmacology*
Cell Line
Chlorocebus aethiops
Dogs
Hexetidine / pharmacology*
Humans
Influenza A Virus, H5N1 Subtype / drug effects
Influenza A Virus, H5N1 Subtype / pathogenicity
Respiratory Tract Infections / prevention & control
Vero Cells

Substances

Antiviral Agents
Hexetidine