From Nano to Macro: Multiscale Materials for Improved Stem Cell Culturing and Analysis

Jeroen Leijten; Ali Khademhosseini

doi:10.1016/j.stem.2015.12.013

From Nano to Macro: Multiscale Materials for Improved Stem Cell Culturing and Analysis

Cell Stem Cell. 2016 Jan 7;18(1):20-4. doi: 10.1016/j.stem.2015.12.013.

Authors

Jeroen Leijten¹, Ali Khademhosseini²

Affiliations

¹ Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
² Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia. Electronic address: alik@rics.bwh.harvard.edu.

PMID: 26748753
DOI: 10.1016/j.stem.2015.12.013

Abstract

Stem cells respond to nanoscale, microscale, and macroscale cues, such as matrix, growth factors, and niche organization, which are difficult to physiologically recapitulate in culture. We discuss how utilizing bioengineering approaches to manipulate and integrate spatiotemporal cues across these discrete length scales can improve traditional methods for controlling cell fate.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Biocompatible Materials / chemistry
Bioengineering / methods
Cell Culture Techniques*
Cell Lineage
Cells, Cultured
Humans
Mesenchymal Stem Cells / cytology
Nanotechnology / methods
Stem Cells / cytology*
Tissue Engineering / methods*

Substances

Biocompatible Materials

Abstract

Publication types

MeSH terms

Substances

Grants and funding