Gut Microbiota Cool-Down Burning Fat! The Immune Hypothesis

Remy Burcelin; Céline Pomié

doi:10.1016/j.tem.2015.12.002

Gut Microbiota Cool-Down Burning Fat! The Immune Hypothesis

Trends Endocrinol Metab. 2016 Feb;27(2):67-68. doi: 10.1016/j.tem.2015.12.002. Epub 2015 Dec 30.

Authors

Remy Burcelin¹, Céline Pomié²

Affiliations

¹ Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France; Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Team 2 : 'Intestinal Risk Factors, Diabetes, Dyslipidemia' F-31432 Toulouse Cedex 4, France. Electronic address: Remy.burcelin@inserm.fr.
² Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France; Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Team 2 : 'Intestinal Risk Factors, Diabetes, Dyslipidemia' F-31432 Toulouse Cedex 4, France.

PMID: 26747615
DOI: 10.1016/j.tem.2015.12.002

Abstract

Obesity is characterized by gut microbiota dysbiosis and reduced thermogenic activity of brown adipose tissue. A recent study reveals that gut microbiota hampers the emergence of thermogenic brown fat cells named beige cells within white fat depots via a mechanism that involves the control of macrophages and eosinophil infiltration.

Keywords: beige fat; gut microbiota; obesity; type 2 immune response.

Publication types

Comment

MeSH terms

Adipose Tissue, Brown / metabolism*
Adipose Tissue, White / metabolism*
Animals
Microbiota*
Obesity / microbiology*
Obesity / pathology*