Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy

Meiying Wu; Qingshuo Meng; Yu Chen; Lingxia Zhang; Mengli Li; Xiaojun Cai; Yaping Li; Pengcheng Yu; Linlin Zhang; Jianlin Shi

doi:10.1002/adma.201505524

Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy

Adv Mater. 2016 Mar 9;28(10):1963-9. doi: 10.1002/adma.201505524. Epub 2016 Jan 7.

Authors

Affiliations

¹ State Key Laboratory of High Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai, 200050, P. R. China.
² Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, P. R. China.

PMID: 26743228
DOI: 10.1002/adma.201505524

Abstract

A stability-difference-selective bond-breakage strategy for the fabrication of largepore-sized hollow mesoporous organosilica nanoparticles (HMONs) is successfully developed. Moreover, surfacefunctionalized HMONs are successfully constructed to simultaneously deliver P-gp modulator siRNA and anticancer drug doxorubicin to reverse the multidrug resistance of cancer cells.

Keywords: cancer therapy; gene delivery; large pores; multidrug resistance; nanoparticles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alloys / chemistry
Antineoplastic Agents / chemistry
Antineoplastic Agents / therapeutic use
Catalysis
Drug Carriers / chemistry*
Gene Transfer Techniques*
Humans
Metals / chemistry
Nanotubes / chemistry
Neoplasms / drug therapy
Oxidation-Reduction
Oxides / chemistry
Photoelectron Spectroscopy
Porosity
Silicon Dioxide / chemistry*

Substances

Alloys
Antineoplastic Agents
Drug Carriers
Metals
Oxides
Silicon Dioxide