Effects of S-Nitrosoglutathione on the Expression of MMP-1 mRNA in HT1080 Cells during Hypoxic Hypoxia

Bull Exp Biol Med. 2016 Jan;160(3):319-21. doi: 10.1007/s10517-016-3160-5. Epub 2016 Jan 8.

Abstract

Synthetic antioxidant S-nitrosoglutathione suppressed the expression of MMP-1 mRNA in HT1080 cells exposed to hypoxic hypoxia; hyperexpression of superoxide dismutase 2 increased and hyperexpression of catalase inhibited the expression of MMP-1 mRNA in HT1080 cells.

Keywords: antioxidants; cell culture; hypoxia; matrix metalloproteinase-1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antioxidants / pharmacology
  • Catalase / metabolism
  • Cell Hypoxia / drug effects
  • Cell Line
  • Humans
  • Matrix Metalloproteinase 1 / genetics*
  • RNA, Messenger / genetics*
  • S-Nitrosoglutathione / pharmacology*
  • Superoxide Dismutase / metabolism

Substances

  • Antioxidants
  • RNA, Messenger
  • S-Nitrosoglutathione
  • Catalase
  • Superoxide Dismutase
  • superoxide dismutase 2
  • MMP1 protein, human
  • Matrix Metalloproteinase 1