Abstract
Synthetic antioxidant S-nitrosoglutathione suppressed the expression of MMP-1 mRNA in HT1080 cells exposed to hypoxic hypoxia; hyperexpression of superoxide dismutase 2 increased and hyperexpression of catalase inhibited the expression of MMP-1 mRNA in HT1080 cells.
Keywords:
antioxidants; cell culture; hypoxia; matrix metalloproteinase-1.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antioxidants / pharmacology
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Catalase / metabolism
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Cell Hypoxia / drug effects
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Cell Line
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Humans
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Matrix Metalloproteinase 1 / genetics*
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RNA, Messenger / genetics*
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S-Nitrosoglutathione / pharmacology*
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Superoxide Dismutase / metabolism
Substances
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Antioxidants
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RNA, Messenger
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S-Nitrosoglutathione
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Catalase
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Superoxide Dismutase
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superoxide dismutase 2
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MMP1 protein, human
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Matrix Metalloproteinase 1