Of the relevant people suffering from headaches only about 20% consult a physician until the age of 35. Accordingly, the pharmacy poses the most commonly used contact point for the consultation of patients with headaches. Besides the therapy of headaches with non-opioid analgesics, including non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen and analgesics without anti-inflammatory action such as paracetamol, two triptans are available for self-medication of prior diagnosed migraine. The professional guidance of patients in using these drugs requires a subtle knowledge of contraindications, unwanted side effects and interactions.