Severe toxicity of chemotherapy against advanced soft tissue sarcoma in Werner's syndrome: Ifosfamide-induced encephalopathy with central diabetes insipidus

J Orthop Sci. 2016 May;21(3):403-6. doi: 10.1016/j.jos.2015.06.012. Epub 2015 Jun 30.

Authors

Shinji Tsukamoto¹, Yukako Kurematsu², Kanya Honoki³, Akira Kido³, Satoshi Somekawa⁴, Daisuke Kaya², Tomomi Sadamitsu², Hiroshi Fukui², Yasuhito Tanaka³

Affiliations

¹ Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan. Electronic address: shinji104@mail.goo.ne.jp.
² Department of Gastroenterology, Endocrinology and Metabolism, Nara Medical University, Kashihara, Nara, Japan.
³ Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan.
⁴ Department of Cardiorenal and Metabolic Medicine, Nara Medical University, Kashihara, Nara, Japan.

PMID: 26740452
DOI: 10.1016/j.jos.2015.06.012

No abstract available

Publication types

Case Reports

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Brain Diseases / chemically induced*
Brain Diseases / diagnostic imaging
Diabetes Insipidus, Neurogenic / chemically induced*
Diabetes Insipidus, Neurogenic / diagnostic imaging
Doxorubicin / administration & dosage
Doxorubicin / adverse effects*
Follow-Up Studies
Humans
Ifosfamide / administration & dosage
Ifosfamide / adverse effects*
Infusions, Intravenous
Male
Middle Aged
Neoplasm Invasiveness / pathology
Neoplasm Staging
Respiratory Distress Syndrome / chemically induced
Respiratory Distress Syndrome / diagnostic imaging
Retroperitoneal Neoplasms / drug therapy*
Retroperitoneal Neoplasms / pathology
Risk Assessment
Sarcoma / drug therapy*
Sarcoma / pathology
Tomography, X-Ray Computed / methods
Werner Syndrome / diagnosis
Werner Syndrome / therapy

Substances

Doxorubicin
Ifosfamide