Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

Victoria J B Gotham; Melanie C Hobbs; Ryan Burgin; David Turton; Carl Smythe; Iain Coldham

doi:10.1039/c5ob02482j

Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

Org Biomol Chem. 2016 Feb 7;14(5):1559-63. doi: 10.1039/c5ob02482j.

Authors

Victoria J B Gotham¹, Melanie C Hobbs², Ryan Burgin², David Turton³, Carl Smythe³, Iain Coldham²

Affiliations

¹ Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk and Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.
² Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. i.coldham@sheffield.ac.uk.
³ Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.

Abstract

During efforts to prepare the known compound , a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dose-Response Relationship, Drug
Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
Heterocyclic Compounds, 4 or More Rings / chemistry
Heterocyclic Compounds, 4 or More Rings / pharmacology*
Molecular Structure
Nonsense Mediated mRNA Decay / drug effects*
RNA, Messenger / metabolism*

Substances

Heterocyclic Compounds, 4 or More Rings
RNA, Messenger
VG1 compound

Grants and funding

MC_PC_12022/MRC_/Medical Research Council/United Kingdom