Hepatoprotective triterpenes from the gum resin of Boswellia carterii

Fitoterapia. 2016 Mar:109:266-73. doi: 10.1016/j.fitote.2015.12.018. Epub 2015 Dec 29.

Abstract

Ten tirucallane-type triterpenes named boscartene A-J and a nor-tetracyclic triterpene boscartene K, together with ten known compounds were isolated from the gum resin of Boswellia carterii Birdw. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis. In vitro assay, some of these compounds (10 μM) showed moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage.

Keywords: Boscartene A–K; Boswellia carterii; Hepatoprotective activities; Tirucallane-type triterpenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boswellia / chemistry*
  • Cell Line
  • Cytoprotection
  • Galactosamine / adverse effects
  • Hepatocytes / drug effects*
  • Humans
  • Molecular Structure
  • Resins, Plant / chemistry*
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification

Substances

  • Resins, Plant
  • Triterpenes
  • tirucallane
  • Galactosamine