Mismatch repair and homeologous recombination

Abstract

DNA mismatch repair influences the outcome of recombination events between diverging DNA sequences. Here we discuss how mismatch repair proteins are active in different homologous recombination subpathways and specific reaction steps, resulting in differential modulation of these recombination events, with a focus on the mechanism of heteroduplex rejection during the inhibition of recombination between slightly diverged (homeologous) DNA sequences.

Keywords: Antirecombination; Heteroduplex rejection; Homeologous recombination; Homologous recombination; Mismatch repair.