Regulation of nuclear morphology by actomyosin components and cell geometry

Annu Int Conf IEEE Eng Med Biol Soc. 2015:2015:342-5. doi: 10.1109/EMBC.2015.7318369.

Abstract

Extracellular microenvironmental signals modulate the coupling between cytoskeleton to nuclear links to regulate gene expression profiles. However the influence of actomyosin assembly on the morphology of the nucleus is not well understood. In this paper, we quantitatively demonstrate the role of cell geometry and specific actomyosin molecular components in their control of nuclear morphology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / genetics
  • Actins / metabolism
  • Actins / ultrastructure
  • Actomyosin / genetics
  • Actomyosin / metabolism*
  • Animals
  • Cell Nucleus / metabolism
  • Cell Nucleus / physiology*
  • Cell Nucleus / ultrastructure
  • Cells, Cultured
  • Cytoskeleton / metabolism
  • Drosophila / cytology
  • Image Processing, Computer-Assisted
  • Mice
  • Molecular Imaging
  • NIH 3T3 Cells / cytology
  • RNA Interference

Substances

  • Actins
  • Actomyosin