Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7

Molecules. 2015 Dec 28;21(1):E31. doi: 10.3390/molecules21010031.

Abstract

Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3-5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC50 value of 4.2 μM.

Keywords: Aspergillus fumigatus; cell growth inhibition; marine-derived fungus; terpenoid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Aspergillus fumigatus / chemistry*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Structure
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology*
  • U937 Cells

Substances

  • Antineoplastic Agents
  • Terpenes