Enantioselective syntheses of indanes: from organocatalysis to C-H functionalization

Chem Soc Rev. 2016 Mar 7;45(5):1368-86. doi: 10.1039/c5cs00622h.

Abstract

The indanyl core is ubiquitous in a large variety of drugs and natural products. Importantly, the ever-increasing demand for chiral catalysts bearing this scaffold calls for state of the art methods allowing for a step-economical enantioselective access to this structural motif. We herein summarize the asymmetric syntheses of indanes with a particular focus on asymmetric catalysis, covering the literature of the last decade until July 2015.

Publication types

  • Review

MeSH terms

  • Catalysis
  • Indans / chemical synthesis*
  • Indans / chemistry
  • Molecular Conformation
  • Organic Chemicals / chemistry*
  • Stereoisomerism

Substances

  • Indans
  • Organic Chemicals