Human Radiation Dosimetry of [(18)F]AV-1451(T807) to Detect Tau Pathology

Mol Imaging Biol. 2016 Aug;18(4):479-82. doi: 10.1007/s11307-015-0924-7.

Abstract

Purpose: [(18)F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [(18)F]AV-1451 in humans.

Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [(18)F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software.

Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq.

Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [(18)F]AV-1451 could be used in multiple PET scans of the same subject per year.

Keywords: Dosimetry; PET; Tau; [18F]AV-1451.

Publication types

  • Clinical Trial

MeSH terms

  • Carbolines / chemistry*
  • Dose-Response Relationship, Radiation
  • Female
  • Fluorine Radioisotopes / chemistry*
  • Humans
  • Male
  • Middle Aged
  • Radiometry*
  • Tauopathies / diagnosis*
  • Tauopathies / diagnostic imaging*
  • Time Factors
  • Tissue Distribution
  • Whole Body Imaging

Substances

  • Carbolines
  • Fluorine Radioisotopes
  • 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole