The catalytic enantioselective synthesis of tetrahydroquinolines containing all-carbon quaternary stereocenters via the formation of aza-ortho-xylylene with 1,2-dihydroquinoline as a precursor

Abstract

Tetrahydroquinolines () with an all-carbon quaternary stereocenter were effectively obtained via the in situ formation of aza-ortho-xylylene () with easily accessible 1,2-dihydroquinolines as precursors. The reaction was rationalized with chiral phosporic acid to afford chiral with high yield and excellent enantioselectivity.