Rh(I)-Catalyzed Insertion of Allenes into C-C Bonds of Benzocyclobutenols

Org Lett. 2016 Jan 15;18(2):328-31. doi: 10.1021/acs.orglett.5b03518. Epub 2016 Jan 4.

Abstract

Herein we report a Rh(I)-catalyzed two carbon insertion into C-C bonds of benzocyclobutenols by employing symmetrical and unsymmetrical allenes. This reaction provides rapid access to alkylidene tetralins bearing two adjacent stereogenic centers in good yields and diasteroselectivities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkadienes / chemistry*
  • Butanols / chemistry*
  • Carbon / chemistry
  • Catalysis
  • Molecular Structure
  • Rhodium / chemistry*
  • Stereoisomerism

Substances

  • Alkadienes
  • Butanols
  • propadiene
  • Carbon
  • Rhodium