A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model

Yaping Liu; Huilong Ma; Liangwei Zhang; Yajing Cui; Xiaoting Liu; Jianguo Fang

doi:10.1039/c5cc09998f

A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model

Chem Commun (Camb). 2016 Feb 7;52(11):2296-9. doi: 10.1039/c5cc09998f.

Authors

Yaping Liu¹, Huilong Ma¹, Liangwei Zhang¹, Yajing Cui¹, Xiaoting Liu¹, Jianguo Fang¹

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. fangjg@lzu.edu.cn.

PMID: 26725656
DOI: 10.1039/c5cc09998f

Abstract

The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal*
Mitochondria / enzymology*
Molecular Probes*
Parkinson Disease / enzymology*
Thioredoxin-Disulfide Reductase / metabolism*

Substances

Molecular Probes
Thioredoxin-Disulfide Reductase