Hsa-miR-449a genetic variant is associated with risk of gastric cancer in a Chinese population

Int J Clin Exp Pathol. 2015 Oct 1;8(10):13387-92. eCollection 2015.

Abstract

Gastric cancer (GC) is one of the most common malignancies and one of the major causes of cancer-related deaths worldwide. In the present study, we investigated the association between miR-449a rs112310158 SNP and GC risk. Our findings revealed that a variant GG genotype increased the risk of occurrence of GC compared to a wild type AA genotype (OR = 2.542, 95% CI: 1.304-4.954, P = 0.005). Specifically, the G allele reduced the risk of occurrence of cervical cancer in women compared to the A allele (OR = 1.279, 95% CI: 1.012-1.617, P = 0.043). In conclusion, our findings suggest that miR-449a rs112310158 is a genetic risk factor for GC.

Keywords: Gastric cancer; miR-449a; polymorphism.

MeSH terms

  • Adult
  • Aged
  • Asian People / genetics*
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Immunohistochemistry
  • Male
  • MicroRNAs / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Real-Time Polymerase Chain Reaction
  • Stomach Neoplasms / genetics*

Substances

  • MIRN449 microRNA, human
  • MicroRNAs