Expression of MTA2 and Ki-67 in hepatocellular carcinoma and their correlation with prognosis

Int J Clin Exp Pathol. 2015 Oct 1;8(10):13083-9. eCollection 2015.

Abstract

The aim of this study was to investigate the relationship among MTA2, Ki-67 and HCC patient prognosis. Tissue microarray and immunohistochemistry were used to detect the expression of MTA2 and Ki-67 in HCC samples and corresponding adjacent samples. We found MTA2 and Ki-67 were both increased in HCC tissues than those in adjacent tissues and nuclear MTA2 was associated with Ki-67 (P = 0.019). Moreover, nuclear MTA2 was a risk factor of distant metastasis in patients with HCC andKi-67 showed a negative correlation with histological grade (P < 0.05, P < 0.01, respectively). Multivariate Cox model analysis revealed that Ki-67 expression was an independent prognosis factor in HCC patients (P = 0.020). These results indicated there might be a tight correlation among MTA2, Ki-67 and HCC prognosis. MTA2 combined with Ki-67 might be used to predict HCC patient prognosis.

Keywords: HCC; Ki-67; MTA2; liver cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / mortality
  • Carcinoma, Hepatocellular / pathology*
  • Histone Deacetylases / analysis
  • Histone Deacetylases / biosynthesis*
  • Humans
  • Immunohistochemistry
  • Kaplan-Meier Estimate
  • Ki-67 Antigen / analysis
  • Ki-67 Antigen / biosynthesis*
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / mortality
  • Liver Neoplasms / pathology*
  • Prognosis
  • Proportional Hazards Models
  • Repressor Proteins / analysis
  • Repressor Proteins / biosynthesis*
  • Tissue Array Analysis

Substances

  • Biomarkers, Tumor
  • Ki-67 Antigen
  • Repressor Proteins
  • MTA2 protein, human
  • Histone Deacetylases