Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells

Feng Li; Janice Ortega; Liya Gu; Guo-Min Li

doi:10.1016/j.dnarep.2015.11.021

Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells

DNA Repair (Amst). 2016 Feb:38:68-74. doi: 10.1016/j.dnarep.2015.11.021. Epub 2015 Dec 8.

Authors

Feng Li¹, Janice Ortega², Liya Gu², Guo-Min Li³

Affiliations

¹ Department of Medical Genetics, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
² Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern CA Keck School of Medicine, Los Angeles, CA 90033, USA.
³ Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern CA Keck School of Medicine, Los Angeles, CA 90033, USA; Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing 100084, China. Electronic address: guominli@usc.edu.

Abstract

DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.

Keywords: Deacetylase; H3K36me3; Histone methylation; MSH2; PCNA; Phosphorylation; Ubiquitination.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chromatin Assembly and Disassembly
DNA Mismatch Repair*
Eukaryotic Cells / metabolism*
Histone Code*
Humans
Models, Biological
Protein Processing, Post-Translational*

Abstract

Publication types

MeSH terms

Grants and funding