Absorption and excretion of Tetrabromobisphenol A in male Wistar rats following subchronic dermal exposure

Chemosphere. 2016 Mar:146:189-94. doi: 10.1016/j.chemosphere.2015.12.027. Epub 2015 Dec 24.

Abstract

Tetrabromobisphenol A (TBBPA) is widely used as a flame retardant and frequently detected in environmental and biological samples. In this study, male Wistar rats were repeatedly exposed by dermal application to 20, 60, 200 and 600 mg TBBPA/kg body weight during 90 days. Concentrations of TBBPA in serum, urine and feces after dermal exposure were determined. TBBPA concentrations in serum ranged from 19.04 to 427.20 g/g lipids. The percentage of TBBPA dose recovered in serum on the 90th day varied from 0.002 ± 0.002% to 0.013 ± 0.008%, and the percentage of dose excreted in urine varied from 0.004 ± 0.002% to 0.072 ± 0.027%, while the percentage of dose recovered in feces were 3.30 ± 0.61% to 11.13 ± 3.16%. The results showed that about 3.31-11.21% TBBPA was absorbed dermally under different dosing regimens. TBBPA was excreted mainly in feces and small only amounts were recovered in urine.

Keywords: Absorption; Dermal exposure; Tetrabromobisphenol A; Urinary and fecal excretion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Animals
  • Dose-Response Relationship, Drug
  • Environmental Pollutants / blood
  • Environmental Pollutants / pharmacokinetics*
  • Environmental Pollutants / urine
  • Feces / chemistry*
  • Flame Retardants / pharmacokinetics*
  • Male
  • Metabolic Clearance Rate
  • Polybrominated Biphenyls / blood
  • Polybrominated Biphenyls / pharmacokinetics*
  • Polybrominated Biphenyls / urine
  • Rats
  • Rats, Wistar
  • Skin / drug effects*
  • Skin / metabolism
  • Skin Absorption / drug effects*
  • Time Factors
  • Tissue Distribution

Substances

  • Environmental Pollutants
  • Flame Retardants
  • Polybrominated Biphenyls
  • tetrabromobisphenol A