Kidney dendritic cells(DC) play important roles in the pathogenesis of kidney diseases. Kidney DC presents anti-inflammatory effects in certain kidney diseases, sometimes presents pro-inflammation in other diseases, and sometimes their effects are changing in different stages of the disease, suggesting that the differentiation and function of kidney DC may be influenced by microenvironment. This article reviews the origin and distribution of kidney DC subsets and their roles in the pathogenesis of kidney diseases such as lupus nephritis and pyelonephritis, and the functional regulation of kidney DC by proximal tubule epithelial cells.
肾脏树突状细胞(DC)在肾脏疾病的发生发展中扮演重要角色。肾脏DC在某些肾脏疾病中可表现为抗炎作用, 而在另一些肾脏疾病中表现为促炎作用, 甚至在某一疾病过程中其作用可发生变化, 提示肾脏微环境对肾脏DC的分化和功能具有重要的影响。本文就肾脏DC的来源、种类和分布, 肾脏DC在狼疮性肾炎和肾盂肾炎等肾脏疾病发生发展中的作用和机制, 以及近端小管上皮细胞对DC功能调节作用等方面的研究进展作一综述。