Ubiquitin-specific protease(USP), which belongs to cysteine protease, is an important member of the deubiquitinating enzyme family(DUB). USP plays an important role in the immune response against viral infections, in which it can regulate the production of type I interferon through various ways to initiate or weaken the antiviral immune response. USP2b, USP3, USP18, USP25, UL36USP and HAUSP play a role of antivirus; while USP4, USP13, USP15 and USP17 negatively regulate antiviral immune response. In this article we review the recent progress on roles of USP family in antiviral immune response.
泛素特异性蛋白酶(USP)属于半胱氨酸蛋白酶, 是去泛素化酶家族的重要成员之一。USP家族分子通过多种途径正向或负向调控I型干扰素的产生, 从而启动或削弱抗病毒感染免疫应答。例如USP2b、USP3、USP18、USP25、UL36USP和HAUSP发挥抗病毒效应, 而USP4、USP13、USP15和USP17则对机体的抗病毒免疫应答起负向调节的作用。本文对USP家族成员在抗病毒感染免疫应答中的调控作用及研究进展进行了综述。