Neosartoryadins A and B, Fumiquinazoline Alkaloids from a Mangrove-Derived Fungus Neosartorya udagawae HDN13-313

Guihong Yu; Guoliang Zhou; Meilin Zhu; Wei Wang; Tianjiao Zhu; Qianqun Gu; Dehai Li

doi:10.1021/acs.orglett.5b02964

Neosartoryadins A and B, Fumiquinazoline Alkaloids from a Mangrove-Derived Fungus Neosartorya udagawae HDN13-313

Org Lett. 2016 Jan 15;18(2):244-7. doi: 10.1021/acs.orglett.5b02964. Epub 2015 Dec 29.

Authors

Guihong Yu¹, Guoliang Zhou¹, Meilin Zhu¹, Wei Wang¹, Tianjiao Zhu¹, Qianqun Gu¹, Dehai Li¹

Affiliation

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.

PMID: 26713369
DOI: 10.1021/acs.orglett.5b02964

Abstract

Neosartoryadins A (1) and B (2), both with a unique 6/6/6/5 quinazoline ring system connected directly to a 6/5/5 imidazoindolone ring, together with three biogenetically related compounds 3-5, were isolated from the endophytic fungus Neosartorya udagawae HDN13-313. The absolute configurations of new compounds 1-4 were established. Compounds 1 and 2 displayed anti-influenza virus A (H1N1) activities with IC50 values of 66 and 58 μM, respectively (ribavirin as positive control, IC50 = 94 μM).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Influenza A Virus, H1N1 Subtype / drug effects
Inhibitory Concentration 50
Molecular Structure
Neosartorya / chemistry*
Nuclear Magnetic Resonance, Biomolecular
Quinazolines / chemistry
Quinazolines / isolation & purification*
Quinazolines / pharmacology
Rhizophoraceae / microbiology
Ribavirin / pharmacology

Substances

Alkaloids
Quinazolines
neosartoryadin A
neosartoryadin B
Ribavirin