KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1912-7. doi: 10.1128/AAC.02756-15.

Abstract

In a 2008-2011 survey, 17,945 patients in 18 hospital units in Europe and Israel were screened for carriage of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae, resulting in identification of 124 positive patients. The isolates were dominated by Klebsiella pneumoniae sequence type 258 (ST258) KPC-2 and ST512 KPC-3, mainly from Greece and Italy, respectively, whereas Israeli isolates were of diverse species, clones, and KPC variants. Various blaKPC platforms were observed, among which IncFIIK-FIBK plasmids with blaKPC-2/-3 genes in the Tn4401a transposon prevailed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Proteins / biosynthesis*
  • Bacterial Proteins / genetics*
  • Carbapenems / therapeutic use*
  • Citrobacter freundii / drug effects
  • Citrobacter freundii / genetics
  • Citrobacter freundii / isolation & purification
  • DNA Transposable Elements / genetics
  • Enterobacteriaceae Infections / drug therapy*
  • Enterobacteriaceae Infections / microbiology
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Escherichia coli / isolation & purification
  • Europe
  • Humans
  • Israel
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / isolation & purification
  • Plasmids / genetics
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • DNA Transposable Elements
  • beta-lactamase KPC-2
  • beta-Lactamases
  • beta-lactamase KPC-3, Klebsiella pneumoniae
  • carbapenemase