Abstract
In a 2008-2011 survey, 17,945 patients in 18 hospital units in Europe and Israel were screened for carriage of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae, resulting in identification of 124 positive patients. The isolates were dominated by Klebsiella pneumoniae sequence type 258 (ST258) KPC-2 and ST512 KPC-3, mainly from Greece and Italy, respectively, whereas Israeli isolates were of diverse species, clones, and KPC variants. Various blaKPC platforms were observed, among which IncFIIK-FIBK plasmids with blaKPC-2/-3 genes in the Tn4401a transposon prevailed.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Proteins / biosynthesis*
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Bacterial Proteins / genetics*
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Carbapenems / therapeutic use*
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Citrobacter freundii / drug effects
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Citrobacter freundii / genetics
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Citrobacter freundii / isolation & purification
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DNA Transposable Elements / genetics
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Enterobacteriaceae Infections / drug therapy*
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Enterobacteriaceae Infections / microbiology
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Escherichia coli / drug effects
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Escherichia coli / genetics
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Escherichia coli / isolation & purification
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Europe
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Humans
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Israel
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / isolation & purification
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Plasmids / genetics
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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DNA Transposable Elements
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beta-lactamase KPC-2
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beta-Lactamases
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beta-lactamase KPC-3, Klebsiella pneumoniae
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carbapenemase