Lung cancer causes the most number of deaths from cancer. Non-small cell lung cancer (NSCLC), including squamous cell carcinoma, large cell carcinoma, and adenocarcinoma, is responsible for more than 80% of primary lung cancer cases. As metastasis is the main cause of death, understanding the mechanisms underlying NSCLC metastasis are essential for improving the treatment of this disease. Recent studies have found that microRNAs (miRNAs) are involved in the progression from cell invasion and migration to final tumor metastasis of NSCLC. In this review, we will discuss the role and mechanisms of miRNAs related to the metastasis of NSCLC.