Oral purpura as the first manifestation of primary systemic amyloidosis

Robert Stuart McCormick; Philip Sloan; David Farr; Marco Carrozzo

doi:10.1016/j.bjoms.2015.11.024

Oral purpura as the first manifestation of primary systemic amyloidosis

Br J Oral Maxillofac Surg. 2016 Jul;54(6):697-9. doi: 10.1016/j.bjoms.2015.11.024. Epub 2015 Dec 18.

Authors

Robert Stuart McCormick¹, Philip Sloan², David Farr³, Marco Carrozzo⁴

Affiliations

¹ Specialty trainee (ST3) in Oral and Maxillofacial Surgery, James Cook University Hospital, South Tees Hospitals NHS Foundation Trust, Marton Road, Middlesbrough, TS4 3BW, UK. Electronic address: robertmccormick@nhs.net.
² Professor of Oral and Maxillofacial Pathology, School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK. Electronic address: philip.sloan@ncl.ac.uk.
³ Consultant Oral and Maxillofacial Surgeon, James Cook University Hospital, South Tees Hospitals NHS Foundation Trust, Marton Road, Middlesbrough, TS4 3BW, UK. Electronic address: david.farr@stees.nhs.uk.
⁴ Professor of Oral Medicine, School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK. Electronic address: Marco.Carrozzo@newcastle.ac.uk.

PMID: 26708800
DOI: 10.1016/j.bjoms.2015.11.024

Abstract

Oral blood blisters and purpura are rare features of primary systemic amyloidosis (amyloid light-chain (AL) amyloidosis). We report a case in which these unusual presentations led to a diagnosis of amyloidosis, which enabled effective treatment before organ failure.

Keywords: Bullae; Oral purpura; Systemic amyloidosis.

Publication types

Case Reports

MeSH terms

Humans
Immunoglobulin Light-chain Amyloidosis / complications
Immunoglobulin Light-chain Amyloidosis / diagnosis*
Purpura / etiology*