Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease

Wiley Interdiscip Rev RNA. 2016 Mar-Apr;7(2):227-40. doi: 10.1002/wrna.1327. Epub 2015 Dec 27.

Abstract

The single-stranded nucleic acid-binding protein KHSRP (KH-type splicing regulatory protein) modulates RNA life and gene expression at various levels. KHSRP controls important cellular functions as different as proliferation, differentiation, metabolism, and response to infectious agents. We summarize and discuss experimental evidence providing a potential link between changes in KHSRP expression/function and human diseases including neuromuscular disorders, obesity, type II diabetes, and cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Disease Susceptibility*
  • Gene Expression Regulation
  • Humans
  • Immunomodulation
  • Lipid Metabolism
  • Muscle Development
  • Muscles / physiology
  • Neoplasms / genetics
  • Neoplasms / immunology
  • Neoplasms / metabolism
  • Neurons / metabolism
  • RNA Processing, Post-Transcriptional
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Signal Transduction
  • Trans-Activators / chemistry
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*
  • Virus Diseases / immunology
  • Virus Diseases / metabolism
  • Virus Diseases / virology

Substances

  • KHSRP protein, human
  • RNA-Binding Proteins
  • Trans-Activators