Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis

Sophie Trouillet-Assant; Florent Valour; William Mouton; Patrícia Martins-Simões; Sébastien Lustig; Frédéric Laurent; Tristan Ferry; Lyon BJI study group

doi:10.1016/j.diagmicrobio.2015.11.013

Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis

Diagn Microbiol Infect Dis. 2016 Mar;84(3):266-7. doi: 10.1016/j.diagmicrobio.2015.11.013. Epub 2015 Nov 17.

Authors

Sophie Trouillet-Assant¹, Florent Valour², William Mouton³, Patrícia Martins-Simões³, Sébastien Lustig⁴, Frédéric Laurent³, Tristan Ferry²; Lyon BJI study group

Collaborators

Lyon BJI study group:
Florence Ader, François Biron, André Boibieux, Evelyne Braun, Christian Chidiac, Fatiha Daoud, Yves Gillet, Laure Hees, Johanna Lippmann, Patrick Miailhes, Thomas Perpoint, Sandrine Roux, Julien Saison, Marie-Paule Vallat, Florent Valour, Cédric Barrey, Jean-Baptiste Bérard, Fabien Boucher, Olivier Cantin, Joseph Chateau, Frédéric Dalat, Romain Desmarchelier, Michel-Henry Fessy, Mehdi Ismaïl, Timothée Jacquesson, Emmanuel Jouanneau, Sébastien Lustig, Ali Mojallal, Philippe Neyret, Adrien Peltier, Olivier Reynaud, Hristo Shipkov, Francesco Signorelli, Thibault Vermersch, Anthony Viste, Céline Dupieux, Frederic Laurent, Jean-Philippe Rasigade, François Vandenesch, Francesco Giammarile, Marc Janier, Isabelle Morelec, Marie-Claude Gagnieu, Michel Tod, Sylvain Goutelle, Eugenie Mabrut

Affiliations

¹ Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Lyon, France; Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France. Electronic address: sophie.assant@chu-lyon.fr.
² Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Lyon, France; Infectious Diseases Department, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.
³ Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Lyon, France; Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.
⁴ Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Lyon, France; Orthopedic Surgery Department, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.

PMID: 26707070
DOI: 10.1016/j.diagmicrobio.2015.11.013

Abstract

Comparison of methicillin-susceptible Staphylococcus aureus (MSSA) isolates responsible for bone and joint infection (BJI, n=73) and nasal colonization (n=57) revealed similar prevalence of β-lactamase (blaZ) type A production, associated with cefazolin hydrolysis, suggesting that blaZ type A-carrying MSSA isolates implicated in postoperative BJI are not selected by cefazolin prophylaxis.

Keywords: Bone and joint infection; Cefazolin; Prophylaxis; Staphylococcus aureus; β-Lactamase.

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Antibiotic Prophylaxis*
Arthritis, Infectious / drug therapy
Arthritis, Infectious / microbiology
Arthritis, Infectious / prevention & control
Bacterial Infections / drug therapy*
Bacterial Infections / microbiology*
Bacterial Infections / prevention & control
Bone Diseases, Infectious / drug therapy
Bone Diseases, Infectious / microbiology
Bone Diseases, Infectious / prevention & control
Cefazolin / therapeutic use*
Humans
Methicillin Resistance*
Methicillin-Resistant Staphylococcus aureus / drug effects
Methicillin-Resistant Staphylococcus aureus / genetics
Methicillin-Resistant Staphylococcus aureus / isolation & purification
Orthopedic Procedures / adverse effects*
Postoperative Complications*

Substances

Anti-Bacterial Agents
Cefazolin