Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America?

Fernando Mazulis; Claudia Weilg; Carlos Alva-Urcia; Maria J Pons; Juana Del Valle Mendoza

doi:10.1016/j.apjtm.2015.11.014

Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America?

Asian Pac J Trop Med. 2015 Dec;8(12):1079-1080. doi: 10.1016/j.apjtm.2015.11.014. Epub 2015 Nov 14.

Authors

Fernando Mazulis¹, Claudia Weilg¹, Carlos Alva-Urcia¹, Maria J Pons¹, Juana Del Valle Mendoza²

Affiliations

¹ School of Medicine, Research Center of the Health Sciences Faculty, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru.
² School of Medicine, Research Center of the Health Sciences Faculty, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru. Electronic address: jdelvall@upc.edu.pe.

PMID: 26706684
DOI: 10.1016/j.apjtm.2015.11.014

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) is a cytoplasmic enzyme with an important function in cell oxidative damage prevention. Erythrocytes have a predisposition towards oxidized environments due to their lack of mitochondria, giving G6PD a major role in its stability. G6PD deficiency (G6PDd) is the most common enzyme deficiency in humans; it affects approximately 400 million individuals worldwide. The overall G6PDd allele frequency across malaria endemic countries is estimated to be 8%, corresponding to approximately 220 million males and 133 million females. However, there are no reports on the prevalence of G6PDd in Andean communities where bartonellosis is prevalent.

Keywords: Bartonella; Febrile syndrome; G6PD; Glucose-6-phosphate dehydrogenase.

Publication types

Letter